| Objective To explore a new way of thrombolysis—use a nanoscale carrier to assist tissue plasminogen activator (t-PA) for thrombolysis, and compare the thrombolysis efficiency with t-PA treatment.Methods Thirty SD rats were divided into 3 groups, namely saline group (saline 0.1 mL), traditional thrombolytic drug group (t-PA 0.1 mL), and nanocarriers group (carrier loaded with t-PA). Each group of 10 rats was used to establish a rat femoral vein thrombosis model by anesthetized animals, surgical incision, and ferric chloride infiltration. After ferric chloride treatment for 20 min, the drug was intravenously injected from the distal end, and the treatment time was 4 hours. The femoral vein blood flow status was monitored by laser speckle blood flow imaging system every hour. Draw the relative blood flow change curve of each group of samples and conduct statistical analysis.Results The blood perfusion recovery rates of the normal saline group, the pure thrombolytic drug group, and nanocarriers group were -7.80%, 21.36%, and 60.82%, respectively, the difference was statistically significant (P=0.016). The blood flow of the samples in nanocarriers group increased significantly after treatment.Conclusion Compared with the traditional thrombolytic drug treatment t-PA group, the thrombolytic efficiency of the nanocarriers group was higher. Thus the nanocarriers show great promise in thrombus treatment. |
