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新疆单中心骨巨细胞瘤术后复发的相关因素分析
Analysis of related factors for postoperative recurrence of giant cell tumor of bone in single center in Xinjiang
投稿时间:2022-06-23  
DOI:10.3969/j.issn.1672-5972.2023.01.006
中文关键词:  骨巨细胞瘤  复发  危险因素
英文关键词:Giant cell tumor of bone  Recurrence  Risk factors
基金项目:
作者单位邮编
杜俊炜* 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
张强 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
武峻申 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
杨文鹏 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
江仁兵 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
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中文摘要:
      目的 分析新疆单中心骨巨细胞瘤术后复发情况及其危险因素。方法 回顾性分析2011年2月至2021年11月新疆医科大学附属肿瘤医院75例骨巨细胞瘤患者的临床资料。纳入可能影响术后复发的相关因素:性别、年龄、发生部位、是否病理性骨折、是否有软组织肿块、Campanacci分级情况、不同手术方式以及肿瘤长径是否≥4 cm。采用单因素及多因素分析骨巨细胞瘤术后复发的危险因素。结果 纳入75例骨巨细胞瘤患者中,男女比例为0.83∶1,发病高峰在30 ~ 39岁之间,其中有14例患者术后发生复发现象,复发时间为6 ~ 49个月,复发率为18.7%。Campanacci分级、不同手术方式及肿瘤长径是否≥4 cm与骨巨细胞瘤的复发有显著相关性(P<0.05)。多因素Cox分析显示肿瘤长径≥4 cm是骨巨细胞瘤术后复发的独立危险因素。结论 Campanacci分级、不同手术方式及肿瘤长径是否≥4 cm与骨巨细胞瘤术后复发有着密切的关系,其中肿瘤长径≥4 cm是骨巨细胞瘤术后复发的独立危险因素。临床上应严格把握不同手术的适应证,避免术后复发。
英文摘要:
      Objective To analyze the recurrence and risk factors of single-center giant cell tumor of bone in Xinjiang after surgery.Methods The clinical data of 75 patients with giant cell tumors of bone in Affiliated Tumor Hospital of Xinjiang Medical University from February 2011 to November 2021 were retrospectively analyzed. The relevant factors that may affect postoperative recurrence were included: Sex, age, location, pathological fracture, soft tissue mass, Campanacci grade, different surgical methods, and tumor diameter ≥ 4 cm. Univariate and multivariate analysis of risk factors for postoperative recurrence of giant cell tumor of bone were conducted.Results Among the 75 patients with giant cell tumor of bone, the male to female ratio was 0.83∶1. The peak incidence was between 30 and 39 years old. There were 14 patients with postoperative recurrence, the recurrence time was 6-49 months, and the recurrence rate was 18.7%. Campanacci grade, different surgical methods, and tumor length ≥ 4 cm were significantly correlated with the recurrence of giant cell tumor of bone. Multivariate Cox analysis showed that tumor length ≥ 4 cm was an independent risk factor for postoperative recurrence of giant cell tumor of bone.Conclusion Campanacci grade, different surgical methods, and tumor length ≥ 4 cm are closely related to postoperative recurrence of giant cell tumor of bone. Tumor length ≥ 4 cm is an independent risk factor for postoperative recurrence of giant cell tumor of bone. Clinically, we should strictly grasp the indications of different operations to avoid postoperative recurrence.
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