| Objective To investigate the clinical curative effect of limb salvage treatment for children with extremity osteosarcoma.Methods The clinical data of children with limb osteosarcoma in Affiliated Tumor Hospital of Xinjiang Medical University from January 2010 to October 2021 were analyzed retrospectively. The follow-up period was 6-116 months, the average follow-up time was (30.0±27.5) months, and the median survival time was 47 months. According to the follow-up results, the effects of the location of osteosarcoma in children's extremities, preoperative alkaline phosphatase, Enneking stage, surgical methods, the maximum diameter of tumor, pathological type, regular completion of chemotherapy, local recurrence, and postoperative lung metastasis on the prognosis of children were analyzed. Univariate and multivariate analyses were used to analyze the factors affecting the prognosis of limb salvage osteosarcoma in children.Results The ratio of males to females was 1.2∶1. The overall survival rate within 1 year was 82.7%. The overall survival rate within 3 years was 53.6%. The overall survival rate within 5 years was 40.5%. The analysis showed that the maximum diameter of tumor ≥10 cm, regular completion of chemotherapy, tumor necrosis rate, and lung metastasis were independent risk factors affecting the prognosis of children with limb salvage osteosarcoma(P<0.05).Conclusion The maximum diameter of tumor, regular completion of chemotherapy, tumor necrosis rate and lung metastasis can clearly affect the prognosis of children with limb osteosarcoma. Therefore, early detection and early treatment and regular completion of chemotherapy and prevention of lung metastasis are the key to the treatment of osteosarcoma. |
