设为首页 加入收藏 登录旧版
儿童四肢骨肉瘤保肢治疗临床疗效分析
Clinical efficacy analysis of limb salvage treatment for children with extremity osteosarcoma
投稿时间:2022-06-28  
DOI:10.3969/j.issn.1672-5972.2023.05.005
中文关键词:  骨肉瘤  儿童  保肢  预后
英文关键词:Osteosarcoma  Children  Limb salvage  Prognosis
基金项目:骨科生物材料相关:生物医用高分子材料;生物医用无机非金属材料;生物医用金属材料;生物医用复合材料;组织工程与干细胞;纳米生物材料及纳米技术;生物矿化与仿生制备;生物材料的表面修饰及其生物应答特性;生物医学材料的组织再生及临床应用研究;生物材料表征和生物相容性评价;生物力学和力学生物学;生物材料及其3D打印快速成型技术。
作者单位邮编
杜俊炜* 新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
张强新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
武峻申新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
杨文鹏新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
江仁兵新疆医科大学附属肿瘤医院骨与软组织肿瘤及黑色素瘤科新疆 乌鲁木齐830000 830000
摘要点击次数: 97
全文下载次数: 163
中文摘要:
      目的 探讨儿童四肢骨肉瘤保肢治疗临床疗效情况。方法 回顾性分析2010年1月至2021年10月新疆医科大学附属肿瘤医院儿童四肢骨肉瘤保肢患者的临床资料。随访时间6 ~ 116个月,平均随访时间为(30.0±27.5)个月,中位生存时间为47个月。根据随访结果,分析儿童四肢骨肉瘤的发生部位、术前碱性磷酸酶、Enneking分期、手术方式、肿瘤最大直径、病理类型、是否规律完成化疗、是否局部复发以及术后肺转移情况等因素对患者预后的影响。采用单因素及多因素分析影响儿童四肢骨肉瘤保肢预后的因素。结果 男女比例为1.2∶1,1年内总生存率为82.7%,3年内总生存率为53.6%,5年内总生存率为40.5%。经分析显示肿瘤最大直径≥10 cm、是否规律完成化疗、肿瘤坏死率及肺转移情况是影响儿童四肢骨肉瘤保肢患者预后的独立危险因素(P<0.05)。结论 肿瘤最大直径、是否规律完成化疗、肿瘤坏死率及肺转移情况可明确影响儿童四肢骨肉瘤保肢患者预后,因此早发现、早治疗以及全程规律地完成化疗并预防肺转移的发生是治疗骨肉瘤的关键。
英文摘要:
      Objective To investigate the clinical curative effect of limb salvage treatment for children with extremity osteosarcoma.Methods The clinical data of children with limb osteosarcoma in Affiliated Tumor Hospital of Xinjiang Medical University from January 2010 to October 2021 were analyzed retrospectively. The follow-up period was 6-116 months, the average follow-up time was (30.0±27.5) months, and the median survival time was 47 months. According to the follow-up results, the effects of the location of osteosarcoma in children's extremities, preoperative alkaline phosphatase, Enneking stage, surgical methods, the maximum diameter of tumor, pathological type, regular completion of chemotherapy, local recurrence, and postoperative lung metastasis on the prognosis of children were analyzed. Univariate and multivariate analyses were used to analyze the factors affecting the prognosis of limb salvage osteosarcoma in children.Results The ratio of males to females was 1.2∶1. The overall survival rate within 1 year was 82.7%. The overall survival rate within 3 years was 53.6%. The overall survival rate within 5 years was 40.5%. The analysis showed that the maximum diameter of tumor ≥10 cm, regular completion of chemotherapy, tumor necrosis rate, and lung metastasis were independent risk factors affecting the prognosis of children with limb salvage osteosarcoma(P<0.05).Conclusion The maximum diameter of tumor, regular completion of chemotherapy, tumor necrosis rate and lung metastasis can clearly affect the prognosis of children with limb osteosarcoma. Therefore, early detection and early treatment and regular completion of chemotherapy and prevention of lung metastasis are the key to the treatment of osteosarcoma.
查看全文  查看/发表评论  下载PDF阅读器
扫码关注
《生物骨科材料与临床研究》微信公众号