设为首页 加入收藏 登录旧版
PTH在治疗骨质疏松症及其作用机制的研究进展*
The progression of PTH supplements on osteoporosis and its mechanism
  
DOI:
中文关键词:  甲状旁腺激素  骨质疏松  成骨细胞  信号传导
英文关键词:Parathyroid hormone  Osteoporosis  Osteoblast  Signal Transduction
基金项目:
作者单位
张小骞1 邱奕雁1 刘禹舒1 苏萌2 蓝涛2 杨欣建2 陈扬2*  
通讯作者:张小骞1 邱奕雁1 刘禹舒1 苏萌2 蓝涛2 杨欣建2 陈扬2*    
摘要点击次数: 2190
全文下载次数: 1229
中文摘要:
      随着我国逐渐步入老龄化社会,骨质疏松症及其并发症将给社会带来巨大的负担。甲状旁腺激素(Parathyroid hormone, PTH)是由84个氨基酸组成的直链肽,与传统的抗骨质疏松药物不同,其可以调整骨转换状态,重塑骨小梁,使得骨量增加,降低骨质疏松骨折风险,因此在众多抗骨质疏松药物中备受关注。随着对PTH治疗骨质疏松症的研究不断深入,甲状旁腺相关肽PTHrP、甲状旁腺1型受体PTH1R、胰岛素样生长因子1(IGF-1)等先后被发现在PTH激活PTH1R抗骨质疏松中发挥作用,本文将有关研究进展做一综述。
英文摘要:
      As the population ages in our country, osteoporosis disease and its complications will bring huge burden to the society. Parathyroid hormone(PTH),which consists of 84 amino acids linear peptide, unlike traditional anti osteoporosis drug, can adjust the state of bone turnover, reshape the trabecular bone, which leads to increased bone mass and reduces the risk of osteoporosis fracture. Therefore it has attracted much attention in many anti osteoporosis drug. As the further study of PTH treatment of osteoporosis, parathyroid hormone-related peptide(PTHrP), parathyroid hormone type 1 receptor(PTH1R), insulin-like growth factor 1(IGF-1)have been discovered in the PTH activation PTH1R anti osteoporosis function. This review is mean to illustrate the research progress briefly.
查看全文  查看/发表评论  下载PDF阅读器
扫码关注
《生物骨科材料与临床研究》微信公众号