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聚乳酸/矿化胶原复合人工骨修复材料在兔股骨髁松质骨缺损中的应用研究*
PLA/mineralized collagen graft materials for bone repair on a femoral condyle defect model in rabbit
  
DOI:
中文关键词:  聚乳酸  矿化胶原  人工骨  股骨髁  骨缺损  骨修复
英文关键词:PLA  Mineralized collagen  Artificial bone  Femoral condyle  Bone defect  Bone repair
基金项目:
作者单位
何志敏 宋天喜 胡刚 吴晶晶 仇志烨*  
通讯作者:何志敏 宋天喜 胡刚 吴晶晶 仇志烨*    
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中文摘要:
      目的 研究聚乳酸/矿化胶原人工骨修复材料(NBG)在兔股骨髁松质骨缺损中的疗效,以及该材料与自体骨、骨髓混合使用的效果,考察材料的安全性及有效性。方法 在兔双侧股骨髁造成松质骨缺损,将60只雄性大白兔进行不同骨材料植入。试验分为5组:空白(Blank)组、人工骨(NBG)组、人工骨混骨髓(NBG+ABM)组、人工骨混自体骨(NBG+AGB)组、自体骨(AGB)组,通过影像学观察、组织学评价、生物力学分析等方法考察5 组材料的骨修复性能。结果 观察新生骨和周围骨质结合情况,拍摄X线片并进行灰度值分析以及进行CT三维重建分析,不同时间点的组织切片观察,均表明NBG组、NBG+ABM组、NBG+AGB组、AGB组骨修复效果良好,生物力学测试也表明各实验组相对于空白组可以承载较高的压力载荷。AGB组、NBG+AGB组、NBG+ABM组、NBG组修复效果依次降低,但均接近完全修复。结论 聚乳酸/矿化胶原基人工骨修复材料有良好的生物相容性及骨诱导性,是良好的骨植入材料。单独使用即可以获得良好的骨修复效果,也可以和自体骨或骨髓混合使用,修复效果更加明显。
英文摘要:
      Objective To study the efficacy of polylactic acid /mineralized collagen based artificial bone repair material (NBG) in rabbit cancellous bone defect of femoral condyle, as well as the effect of material mixing with the body bone and bone marrow, and to examine the safety and effectiveness of the material. Methods In the rabbit bilateral femoral condyle caused cancellous bone defect, 60 male rabbits were implanted with bone material. The experiment was divided into 5 groups: Blank group, NBG group, NBG+ABM group, NBG+AGB group, AGB group. The X-Ray and CT, histological evaluation, biomechanical analysis and other methods were used to compare the bone repair performance of 5 groups of materials. Results Through the experimental observation of the combination of newborn bone and surrounding bone, taking X photos and analyzing the grayscale value and performing CT 3D reconstruction analysis, tissue slicing observation at different points in time showed that the bone repair ability of NBG, NBG+ABM, NBG+AGB, AGB group was good, and the biomechanics test also showed that each experimental group could carry a higher pressure load relative to the Blank group. The repair effect of AGB, NBG+AGB, NBG+ABM and NBG group was reduced sequentially, but these groups were close to complete repair. Conclusion The results showed that polylactic acid/mineralized collagen based artificial bone had good biocompatibility and osteoinductivity, and was a good bone implant material. It can be used alone to obtain good bone repair effect, or mixed with autologous bone or bone marrow, and the repair effect is more obvious.
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