| Polyetheretherketone(PEEK) has the advantages of good biocompatibility, excellent mechanical properties, and mechanical properties similar to bone tissue, and has been widely used in various clinical fields. However, due to the inherent biological inertia, implants do not integrate with bone tissue, which limits their application as orthopedic implant materials. Improving the bone integration of polyetheretherketone has become a hot topic. Researchers used materials that promoted the proliferation and differentiation of osteoblasts, such as biological ceramics, metal materials, biological factors, with physical or chemical manners; or used surface physical modifications, such as roughness, porosity, nanostructures, to improve their bone integration. With the development of research, the osteogenic activity of polyetheretherketone material has been enhanced, and it has a greater application prospect in clinical. This paper reviewed the methods that used the biological activity of polyetherketone to improve osseointegration in recent years, aiming to provide reference to researchers and provide prospects for the development in the future. |
