Objective To observe the clinical efficacy of platelet rich plasma (PRP) in the treatment of chronic refractory wounds.Methods A total of 52 patients with chronic refractory wounds caused by trauma, pressure ulcers and diabetes were selected from the 920 Hospital of PLA Joint Logical Support Force from December 2019 to December 2020. According to whether patients received PRP treatment, the study subjects were divided into PRP group (32 cases) and normal group (20 cases). All patients received outpatient surgery for complete debridement, and the PRP group was given PRP gel to cover the wound after surgery. The gel was replaced once every 3 days, 3 times as a course of treatment. In the normal group, dressing was routinely changed after surgery, and skin grafting or flap transfer was selected according to the wound healing to accelerate the wound healing. The wound healing effect of the two groups was observed 1 month later.Results Statistics showed that 32 patients in the PRP group received healing under the scab after 2-4 times of PRP gel treatment, with an average of (25.25±4.93) d of complete wound healing and an average of (5.09±3.21) times of dressing change. In the normal group, 16 cases healed after routine dressing change, 3 cases healed after skin grafting, and 1 case healed after pedicled skin flap transfer. The mean time of complete wound healing was (42.95±7.97) d, and the mean dressing change was (24.70±5.70) times. The epidermal growth factor, insulin-like growth factor, platelet derived growth factor, transforming growth factor β and vascular endothelial growth factor in the PRP group were significantly higher than those in the normal group (P<0.05).Conclusion Compared with the traditional treatment, platelet rich plasma can significantly increase the concentration of growth factors in the wound, accelerate the wound healing, shorten the treatment time, reduce the cost of treatment, and alleviate the pain of patients. |